Next Generation DNA Sequencing

Aligned Bio is developing a nanowire-based, long-read DNA sequencer that will provide 8X the amount of genetic information in less time and cost than the industry leaders.

Aligned patented nanowire waveguide technology enables the detection of single fluorophore labels. Acting as a single dye detector with a billion nanowires per flow cell, this patented technology will enable a breakthrough in sequencing cost, throughput and read-length.

ADVANCED BIOMARKER DETECTION

Aligned Bio’s patented nanowire waveguide platform technology improves sensitivity to targeted disease biomarkers by orders of magnitude over standard industry protocols. With this increased sensitivity, Aligned will be enabling the next generation of immunoassays for advanced point of care diagnostics, the use of significantly less fluids and multiplexing.

THE TECHNOLOGY BEHIND THE CAPABILITY

The underlying technology of these two application areas are nanowires of appropriate material and diameter to act like optical fibers that collect, guide and directionally emit light from fluorescent molecules bound to their surface.

This improved sensitivity has been demonstrated repeatably by our partners at Lund University’s Physics and Immunology departments, corporate partners and Chalmers University of Technology.