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REVOLUTIONARY TECHNOLOGY THROUGH INTELLECTUAL PROPERTY

As an innovator of new, next-generation sensor platform technology, intellectual property is a fundamental part of our work at Aligned Bio. Since our earliest days originating out of Lund University, Aligned Bio has been granted 80 patents for technology and processes in our mission to deliver previously unattainable sensitivity at viable costs.

The fabrication of our nanowire platforms utilizes our intellectual property and trade secrets in the areas of:

  • Low cost mass production of nanowire devices via AerotaxyTM;
  • Nanowire alignment, ordering and spacing on various types of platforms; and
  • The use of nanowires as molecular sensors. 
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AEROTAXYTM NANOWIRE PRODUCTION

Aligned Bio’s nanowire technology has its foundations in its patented AerotaxyTM production methodology. AerotaxyTM allows various types of nanowire types and materials to be produced in a continuous flow reactor providing orders of magnitude savings over conventional nanowire growth technologies.

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NANOWIRE ALIGNMENT 

The ability to align, space and orient nanowires is a fundamental core of Aligned Bio’s technology. This ability is both patented and protected via proprietary process recipes and importantly does not require expensive traditional nanowire growth methods. Alignment and orientation has been demonstrated to be robust, repeatable and manufacturable over large areas.

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WAVEGUIDE TECHNOLOGY

The ability of Aligned Bio’s nanowire platforms to increase up to 20X the sensitivity to targeted biomarkers such as proteins, molecules, pathogens etc. resides in Aligned Bio’s waveguided technology. Upon functionalization for particular molecules, the nanowire will emit a concentrated light signal to the top of the wire where it can be read by the optical reader. Industry standard optical detectors are used.

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SINGLE MOLECULE BIOMARKER DETECTION

Aligned Bio’s patented nanowire waveguide platform technology improves sensitivity to targeted disease biomarkers by orders of magnitude over standard industry protocols. With this increased sensitivity, Aligned will be enabling the next generation of immunoassays for advanced point of care diagnostics, the use of significantly less fluids and multiplexing.

NEXT GENERATION DNA SEQUENCING

Aligned Bio is developing a nanowire-based, long-read DNA sequencer that will provide 8X the amount of genetic information in less time and cost than the industry leaders.

Aligned patented nanowire waveguide technology enables the detection of single fluorophore labels. Acting as a single dye detector with a billion nanowires per flow cell, this patented technology will enable a breakthrough in sequencing cost, throughput and read-length.

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THE TECHNOLOGY BEHIND THE CAPABILITY

The underlying technology of these two application areas are nanowires of appropriate material and diameter to act like optical fibers that collect, guide and directionally emit light from fluorescent molecules bound to their surface.

This improved sensitivity has been demonstrated repeatably by our partners at Lund University’s Physics and Immunology departments, corporate partners and Chalmers University of Technology.

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